Blood Coagulation Testing Method Based on Flow Velocity Measurement Using a Surface Plasmon Resonance (spr)-based Microfluidic Device
نویسندگان
چکیده
We propose a blood coagulation testing method based on the measurement of the flow velocity near the bottom surface of a microchannel by using a surface plasmon resonance (SPR)-based microfluidic device. We were able to distinguish the coagulation ability in different human plasma samples by observing the flow velocity change caused by coagulation that occurred at an interface between a plasma sample and a coagulation trigger agent while flowing in a microchannel. Our blood coagulation testing method is simply carried out by placing a 2 μL plasma droplet at the inlet of a straight PDMS microchannel and introducing the sample into the microchannel with passive pumping.
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